Cowboys vs. Steelers is one of the rare non-conference NFL rivalries thanks to their postseason histories. Their three Super Bowl meetings are the most in the history of the game. The two will collide on Sunday Night Football in Week 5, and Pittsburgh is a 2.5-point home favorite in the NFL odds. Steelers vs. Cowboys could be a Super Bowl 59 preview, just like the Chiefs vs. Saints Monday Night Football game, which has Kansas City favored by five according to the latest Week 5 NFL spreads.
There are several other interesting Week 5 NFL matchups outside of prime time on the Week 5 NFL schedule. Ravens vs. Bengals (+2.5) starts at 1 pm ET on Sunday, as does Bills vs. Texans (+1). In the late afternoon, a pair of 2-2 division rivals will compete in Broncos vs Raiders (+2.5). All Week 5 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and NFL predictions you need to make the best Week 5 NFL picks right now..
The model, which simulates each NFL game 10,000 times, raises well over $7,000 for $100 players on an A rating. NFL picks since its inception. The model enters Week 5 of the 2024 NFL season on an incredible 188-131 run on top-rated NFL picks dating back to the 2017 season. It is also on a 42-23 record in A-rated NFL picks as of Week 7 of the 2022 NFL season.
The model has also ranked in the top 10 on NFLPickWatch four of the past six years on straight NFL picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who followed it is way up.
Now, it has turned its attention to the latest Week 5 NFL odds and NFL betting lines on the spread, moneyline, and over-under, and locked in picks for every NFL game. Go here to see each selection.
Top Week 5 NFL predictions
We can tell you that one of the model’s strongest Week 5 NFL picks is the 49ers (-7.5, 49.5) covering the spread against the Cardinals. San Francisco is close to full strength after returning Deebo Samuel and George Kittle last week, and it was evident in its result against New England. The 49ers won 30-13, with the 17-point win being their biggest since Week 13 of last season. The Niners had a season-high 431 yards and forced three turnovers, while Arizona is coming off a 28-point home loss to Washington that is tied for its fifth-largest home loss in the last 35 years.
The 49ers have beaten the Cardinals in four straight meetings, but they haven’t just scraped by as they have blown out their division rivals as each of those wins has come by at least 16 points. The Cardinals enter Week 5 with back-to-back ATS losses, and their straight record of 9-29 since 2022 is the worst in the NFL. The model expects San Francisco’s dominance of Arizona to continue, with the Niners winning by more than two touchdowns and covering as 7.5-point favorites well over 60% of the time. See which other teams to pick here.
Another of its Week 5 NFL betting predictions: the Packers (-3.5, 47.5) cover on the road against the Rams. Green Bay is coming off a loss to Minnesota in which Jordan Love made his comeback and was clearly rusty early. The Packers fell into a 28-0 hole, but they then outscored the Vikings 29-3 over the last 35 minutes of the game. Love set career highs in both passing yards (389) and touchdowns (four) before a matchup with a Rams defense that ranks 31st in both points allowed and yards allowed.
Los Angeles just allowed Caleb Williams to have his best pro game, with career highs in both completion percentage and passer rating, in a loss to the Bruins. LA was also only able to muster one touchdown on offense because that side of the ball has glaring weaknesses. The Rams have the No. 28 rushing offense and are still missing WRs Cooper Kupp and Puka Nacua in the passing game. Love should be much more consistent another week removed from his injury, which has the model predicting that Green Bay (-3.5) covers much more than 50% of the time. The model also says that the Super (47.5) hits in more than 50% of simulations. See which other teams to pick here.
How to make Week 5 NFL picks
The model also called who wins and covers in every other game on the Week 5 NFL schedule and just revealed three teams that win outright at least 70% of the time, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So, what NFL picks can you make with confidence, and which three must-see teams should you lock in right now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a tested computer model that returned well over $7,000.and find out.
Week 5 NFL betting odds, lines, spreads
Get Week 5 NFL picks at SportsLine
Thursday, October 3rd
Pirates at Falcons (-2.5, 43.5)
Sunday, October 6th
Jets vs. Vikings — in London (-2.5, 41.5)
Panthers at Bears (-4, 42.5)
Ravens at Bengal (+2.5, 50.5)
Bills at Texans (+1, 46.5)
Colts at Jaguars (-2.5, 46)
Dolphins at Patriots (+1, 36.5)
Browns at commanders (-3.5, 44)
Raiders at Broncos (-2.5, 37)
Cardinals at 49ers (-7.5, 49.5)
Packers at Rams (+3.5, 48)
Giants at Seahawks (-6, 42)
Cowboys at Steelers (-2.5, 43)
Monday, October 7th
Saints at Chiefs (-5, 42.5)
require.config({“baseUrl”:”https://sportsfly.cbsistatic.com/fly-0788/bundles/sportsmediajs/js-build”,”config”:{“version”:{“fly/components/accordion”:”1.0″,”fly/components/alert”:”1.0″,”fly/components/base”:”1.0″,”fly/components/carousel”:”1.0″,”fly/components/dropdown”:”1.0″,”fly/components/fixate”:”1.0″,”fly/components/form-validate”:”1.0″,”fly/components/image-gallery”:”1.0″,”fly/components/iframe-messenger”:”1.0″,”fly/components/load-more”:”1.0″,”fly/components/load-more-article”:”1.0″,”fly/components/load-more-scroll”:”1.0″,”fly/components/loading”:”1.0″,”fly/components/modal”:”1.0″,”fly/components/modal-iframe”:”1.0″,”fly/components/network-bar”:”1.0″,”fly/components/poll”:”1.0″,”fly/components/search-player”:”1.0″,”fly/components/social-button”:”1.0″,”fly/components/social-counts”:”1.0″,”fly/components/social-links”:”1.0″,”fly/components/tabs”:”1.0″,”fly/components/video”:”1.0″,”fly/libs/easy-xdm”:”2.4.17.1″,”fly/libs/jquery.cookie”:”1.2″,”fly/libs/jquery.throttle-debounce”:”1.1″,”fly/libs/jquery.widget”:”1.9.2″,”fly/libs/omniture.s-code”:”1.0″,”fly/utils/jquery-mobile-init”:”1.0″,”fly/libs/jquery.mobile”:”1.3.2″,”fly/libs/backbone”:”1.0.0″,”fly/libs/underscore”:”1.5.1″,”fly/libs/jquery.easing”:”1.3″,”fly/managers/ad”:”2.0″,”fly/managers/components”:”1.0″,”fly/managers/cookie”:”1.0″,”fly/managers/debug”:”1.0″,”fly/managers/geo”:”1.0″,”fly/managers/gpt”:”4.3″,”fly/managers/history”:”2.0″,”fly/managers/madison”:”1.0″,”fly/managers/social-authentication”:”1.0″,”fly/utils/data-prefix”:”1.0″,”fly/utils/data-selector”:”1.0″,”fly/utils/function-natives”:”1.0″,”fly/utils/guid”:”1.0″,”fly/utils/log”:”1.0″,”fly/utils/object-helper”:”1.0″,”fly/utils/string-helper”:”1.0″,”fly/utils/string-vars”:”1.0″,”fly/utils/url-helper”:”1.0″,”libs/jshashtable”:”2.1″,”libs/select2″:”3.5.1″,”libs/jsonp”:”2.4.0″,”libs/jquery/mobile”:”1.4.5″,”libs/modernizr.custom”:”2.6.2″,”libs/velocity”:”1.2.2″,”libs/dataTables”:”1.10.6″,”libs/dataTables.fixedColumns”:”3.0.4″,”libs/dataTables.fixedHeader”:”2.1.2″,”libs/dateformat”:”1.0.3″,”libs/waypoints/infinite”:”3.1.1″,”libs/waypoints/inview”:”3.1.1″,”libs/waypoints/jquery.waypoints”:”3.1.1″,”libs/waypoints/sticky”:”3.1.1″,”libs/jquery/dotdotdot”:”1.6.1″,”libs/jquery/flexslider”:”2.1″,”libs/jquery/lazyload”:”1.9.3″,”libs/jquery/maskedinput”:”1.3.1″,”libs/jquery/marquee”:”1.3.1″,”libs/jquery/numberformatter”:”1.2.3″,”libs/jquery/placeholder”:”0.2.4″,”libs/jquery/scrollbar”:”0.1.6″,”libs/jquery/tablesorter”:”2.0.5″,”libs/jquery/touchswipe”:”1.6.18″,”libs/jquery/ui/jquery.ui.core”:”1.11.4″,”libs/jquery/ui/jquery.ui.draggable”:”1.11.4″,”libs/jquery/ui/jquery.ui.mouse”:”1.11.4″,”libs/jquery/ui/jquery.ui.position”:”1.11.4″,”libs/jquery/ui/jquery.ui.slider”:”1.11.4″,”libs/jquery/ui/jquery.ui.sortable”:”1.11.4″,”libs/jquery/ui/jquery.ui.touch-punch”:”0.2.3″,”libs/jquery/ui/jquery.ui.autocomplete”:”1.11.4″,”libs/jquery/ui/jquery.ui.accordion”:”1.11.4″,”libs/jquery/ui/jquery.ui.tabs”:”1.11.4″,”libs/jquery/ui/jquery.ui.menu”:”1.11.4″,”libs/jquery/ui/jquery.ui.dialog”:”1.11.4″,”libs/jquery/ui/jquery.ui.resizable”:”1.11.4″,”libs/jquery/ui/jquery.ui.button”:”1.11.4″,”libs/jquery/ui/jquery.ui.tooltip”:”1.11.4″,”libs/jquery/ui/jquery.ui.effects”:”1.11.4″,”libs/jquery/ui/jquery.ui.datepicker”:”1.11.4″}},”shim”:{“liveconnection/managers/connection”:{“deps”:[“liveconnection/libs/sockjs-0.3.4″]},”liveconnection/libs/sockjs-0.3.4”:{“exports”:”SockJS”},”libs/setValueFromArray”:{“exports”:”set”},”libs/getValueFromArray”:{“exports”:”get”},”fly/libs/jquery.mobile-1.3.2″:[“version!fly/utils/jquery-mobile-init”],”libs/backbone.marionette”:{“deps”:[“jquery”,”version!fly/libs/underscore”,”version!fly/libs/backbone”],”exports”:”Marionette”},”fly/libs/underscore-1.5.1″:{“exports”:”_”},”fly/libs/backbone-1.0.0″:{“deps”:[“version!fly/libs/underscore”,”jquery”],”exports”:”Backbone”},”libs/jquery/ui/jquery.ui.tabs-1.11.4″:[“jquery”,”version!libs/jquery/ui/jquery.ui.core”,”version!fly/libs/jquery.widget”],”libs/jquery/flexslider-2.1″:[“jquery”],”libs/dataTables.fixedColumns-3.0.4″:[“jquery”,”version!libs/dataTables”],”libs/dataTables.fixedHeader-2.1.2″:[“jquery”,”version!libs/dataTables”],”https://sports.cbsimg.net/js/CBSi/app/VideoPlayer/AdobePass-min.js”:[“https://sports.cbsimg.net/js/CBSi/util/Utils-min.js”]},”map”:{“*”:{“adobe-pass”:”https://sports.cbsimg.net/js/CBSi/app/VideoPlayer/AdobePass-min.js”,”facebook”:”https://connect.facebook.net/en_US/sdk.js”,”facebook-debug”:”https://connect.facebook.net/en_US/all/debug.js”,”google”:”https://apis.google.com/js/plusone.js”,”google-csa”:”https://www.google.com/adsense/search/async-ads.js”,”google-javascript-api”:”https://www.google.com/jsapi”,”google-client-api”:”https://accounts.google.com/gsi/client”,”gpt”:”https://securepubads.g.doubleclick.net/tag/js/gpt.js”,”hlsjs”:”https://cdnjs.cloudflare.com/ajax/libs/hls.js/1.0.7/hls.js”,”recaptcha”:”https://www.google.com/recaptcha/api.js?onload=loadRecaptcha&render=explicit”,”recaptcha_ajax”:”https://www.google.com/recaptcha/api/js/recaptcha_ajax.js”,”supreme-golf”:”https://sgapps-staging.supremegolf.com/search/assets/js/bundle.js”,”taboola”:”https://cdn.taboola.com/libtrc/cbsinteractive-cbssports/loader.js”,”twitter”:”https://platform.twitter.com/widgets.js”,”video-avia”:”https://vidtech.cbsinteractive.com/avia-js/2.12.0/player/avia.min.js”,”video-avia-ui”:”https://vidtech.cbsinteractive.com/avia-js/2.12.0/plugins/ui/avia.ui.min.js”,”video-avia-gam”:”https://vidtech.cbsinteractive.com/avia-js/2.12.0/plugins/gam/avia.gam.min.js”,”video-avia-hls”:”https://vidtech.cbsinteractive.com/avia-js/2.12.0/plugins/hls/avia.hls.min.js”,”video-avia-playlist”:”https://vidtech.cbsinteractive.com/avia-js/2.12.0/plugins/playlist/avia.playlist.min.js”,”video-ima3″:”https://imasdk.googleapis.com/js/sdkloader/ima3.js”,”video-ima3-dai”:”https://imasdk.googleapis.com/js/sdkloader/ima3_dai.js”,”video-utils”:”https://sports.cbsimg.net/js/CBSi/util/Utils-min.js”,”video-vast-tracking”:”https://vidtech.cbsinteractive.com/sb55/vast-js/vtg-vast-client.js”}},”waitSeconds”:300});
