Many teams raise their level of play under the bright lights, but the Jets don’t seem to be one of them. Anyone looking to make Week 1 NFL picks for the Jets vs. 49ers on Monday Night Football would be wise to know that New York is 0-5 straight-up and against the spread over its last five road prime-time games. However, there is just as much evidence to pick the Jets with Week 1 NFL predictions as San Francisco has failed to cover in their last seven home games according to the latest NFL betting trends. Something has to give way for the 49ers against the Jets, who will wrap up the Week 1 NFL schedule. San Francisco is a 5.5-point favorite, with an Over/Under of 44.5 in the NFL odds.
Whose undefeated streak will finally end in the NFL spreads? All Week 1 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and NFL predictions you need to make the best Week 1 NFL picks right now..
The model, which simulates each NFL game 10,000 times, raises well over $7,000 for $100 players on an A rating. NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks dating back to the 2017 season. It is also on a 39-21 record in A-rated NFL picks since Week 7 of the 2022 NFL season.
The model has also ranked in the top 10 on NFLPickWatch four of the past six years on straight NFL picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who followed it is way up.
Now, it has turned its attention to the latest Week 1 NFL odds and NFL betting lines on the spread, moneyline, and over-under, and locked in picks for every NFL game. Go here to see each selection.
Top Week 1 NFL predictions
We can tell you that one of the model’s strongest Week 1 NFL picks is that the Chargers (-3.5) cover the spread at home against the Raiders. Las Vegas went 4-0 against the spread in Aidan O’Connell’s last four games as a starter, but O’Connell now holds a clipboard with Gardner Minshew starting. The former Colt hasn’t had the same widespread success as his backup, as Minshew enters the 2024 NFL season with three straight ATS losses as a starter. Additionally, the Week 1 history between these teams does not favor Las Vegas as the Chargers have won four straight season openers against the Raiders.
The Jim Harbaugh effect cannot be overstated for LA In his first season with the 49ers, he took a team that ranked 15th in turnover differential to first in his debut season. The Chargers had a similar differential ranking of 16th last year, but their offense is already ahead of San Francisco’s when Harbaugh took over. SportsLine’s model projects Los Angeles to score nearly a touchdown more than the 20.4 points per game they averaged last year, as LA (-3.5) covers well over 60% of the time. See which other teams to pick here.
Another of its Week 1 NFL predictions: the Bills (-6) cover at home against the Cardinals. Being at home is important, as the Bills have hosted the Cardinals five times in franchise history, and they’ve covered all five of those games. Overall, Buffalo is 7-1 against the spread in the last eight meetings with Arizona.
Both teams have dual-threat QBs, but the defenses they’ll be going up against aren’t equal. The model gives Josh Allen the edge in that regard, as he faces a unit that ranked 31st in scoring defense last year, while Kyler Murray must face the fourth-ranked defense. Allen is projected to have one more passing TD than Murray, while also having 20 more rushing yards than the Cards QB. With Buffalo’s defense projected to have twice as many sacks as Arizona’s, the Bills are expected to win by two scores and cover nearly 70% of the time. See which other teams to pick here.
How to make Week 1 NFL picks
The model also made the call on who wins and covers in every other game on the Week 1 NFL schedule and just revealed four teams that win outright more than 70% of the time. You can only get every pick for every game at SportsLine.
So, what NFL picks can you make with confidence, and which four favorites should you lock in right now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a tested computer model that returned well over $7,000.and find out.
Week 1 NFL betting odds, lines, spreads
Get Week 1 NFL picks at SportsLine
Thursday, September 5th
Ravens at Chiefs (-3, 46.5)
Friday, September 6th
Packers vs. Eagles (-2.5, 48.5) — in Brazil
Sunday, September 8th
Steelers at Falcons (-3, 42.5)
Cardinals at Bills (-6, 48)
Titans at Bears (-4.5, 45.5)
Patriots at Bengals (-8.5, 40.5)
Texans at Colts (+2.5, 48.5)
Jaguars at Dolphins (-3, 49.5)
Panthers at Saints (-4, 41.5)
Vikings at Giants (+1, 41.5)
Raiders at Chargers (-3.5, 40.5)
Broncos at Seahawks (-5.5, 42)
Cowboys at Browns (-2.5, 42)
Commanders at Buccaneers (-3.5, 43.5)
Rams at Lions (-3.5, 51)
Monday, September 9
Jets at 49ers (-3.5, 43.5)
