The San Francisco 49ers could have two of their top players back in time for Week 4, which could cause bettors to reconsider backing them when making their Week 4 NFL picks. The defending NFC champions have been plagued by early-season injuries, but George Kittle is expected to return to the field Sunday to help Brock Purdy air out the offense. Star receiver Deebo Samuel is still questionable to play at home against the New England Patriots and could also return for anyone picking the 49ers with their NFL predictions.
San Francisco is a 10.5-point favorite in the NFL odds, and bettors may have run away earlier in the week due to the mounting injuries. Does the potential return of Kittle and Samuel make you rethink backing the 49ers with your Week 4 NFL picks? All Week 4 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and NFL predictions you need to make the best Week 4 NFL picks right now..
The model, which simulates each NFL game 10,000 times, raises well over $7,000 for $100 players on an A rating. NFL picks since its inception. The model enters Week 4 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks dating back to the 2017 season. It is also on a 41-22 list in A-rated NFL picks as of Week 7 of the 2022 NFL season.
The model has also ranked in the top 10 on NFLPickWatch four of the past six years on straight NFL picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who followed it is way up.
Now, it has turned its attention to the latest Week 4 NFL odds and NFL betting lines on the spread, moneyline, and over-under, and locked in picks for every NFL game. Go here to see each selection.
Top Week 4 NFL predictions
We can tell you that one of the model’s strongest Week 4 NFL picks is the Saints (+2.5, 41.5) covering the spread against the Falcons. New Orleans has done very well in this series, winning 10 of the last 13 meetings against Atlanta. The Saints have also done very well as the road underdog, going 5-1 ATS in their last six games against home favorites.
The Saints offense has been especially effective so far this season, as Derek Carr has completed 68% of his passes while Alvin Kamara has racked up 285 rushing yards with four touchdowns. The Falcons have the 28th-ranked rushing defense in the league, so Carr should feel comfortable handing the ball off so the veteran running back can get the Saints into the end zone. See which other teams to pick here.
Another of its Week 4 NFL betting predictions: the Steelers (-2, 40) cover on the road against the Colts. Pittsburgh’s run defense slowed Chargers running back JK Dobbins last week, holding him to just 44 yards on 15 attempts. They will now face Colts running back Jonathan Taylor, who leads a rushing attack that averages 5.4 yards per carry.
Steelers edge rusher TJ Watt has 5.5 sacks, four tackles for loss, 15 tackles and two forced fumbles in five career games against the Colts. He had two sacks and two tackles for loss in the most recent meeting (Week 15 of last season) and is on pace to become the second fastest player to reach 100 career sacks behind Reggie White. SportsLine’s model expects Watt to disrupt again Sunday, one reason why the Steelers cover the spread in well over 50% of simulations. See which other teams to pick here.
How to make Week 4 NFL picks
The model also called who wins and covers in every other game on the Week 4 NFL schedule and just revealed three teams that win outright at least 70% of the time, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So, what NFL picks can you make with confidence, and which three must-see teams should you lock in right now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a tested computer model that returned well over $7,000.and find out.
Week 4 NFL betting odds, lines, spreads
Get Week 4 NFL picks at SportsLine
Sunday, September 29
Saints at Falcons (-2.5, 41.5)
Bengals at Panthers (+4.5, 47)
Rams at Bears (-3, 40.5)
Vikings at Packers (-3, 44)
Jaguars at Texans (-5.5, 44.5)
Steelers at Colts (+2, 40)
Broncos at Jets (-8, 39.5)
Eagles at Buccaneers (+1, 42)
Commanders at Cardinals (-3.5, 49)
Patriots at 49ers (-10.5, 40.5)
Browns at Raiders (+2.5, 36.5)
Chiefs at Chargers (+7, 41.5)
Bills at Ravens (-2.5, 46.5)
Monday, September 30th
Titans at Dolphins (-2.5, 37)
Seahawks at Lions (-3.5, 46.5)
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