The Colts entered the season with high expectations due to the return of quarterback Anthony Richardson, but they are 0-2 entering their matchup against the Bears during the Week 3 NFL schedule. Indianapolis lost to Houston in its opener before falling at Green Bay last week. The Colts are one-point home favorites in the Week 3 NFL spreads while the Bears go on the road for the second week in a row. Which side of that spread should you back with your Week 3 NFL best bets and NFL betting picks? Indianapolis is one of nine winless teams entering the weekend, creating important games across the NFL odds.
Elsewhere, there are multiple NFL matchups with 2-0 teams, as the Vikings (+1.5) host the Texans and Steelers (-2.5) take on the Chargers. All Week 3 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and NFL predictions you need to make the best Week 3 NFL picks right now..
The model, which simulates each NFL game 10,000 times, raises well over $7,000 for $100 players on an A rating. NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks dating back to the 2017 season. It is also on a 41-22 list in A-rated NFL picks as of Week 7 of the 2022 NFL season.
The model has also ranked in the top 10 on NFLPickWatch four of the past six years on straight NFL picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who followed it is way up.
Now, it has turned its attention to the latest Week 3 NFL odds and NFL betting lines on the spread, moneyline, and over-under, and locked in picks for every NFL game. Go here to see each selection.
Top Week 3 NFL predictions
We can tell you that one of the model’s strongest Week 3 NFL picks is the Browns (-6.5, 38.5) covering the spread against the Giants. Cleveland improved to 7-3 in its last 10 September games with an 18-13 win at Jacksonville last week when quarterback Deshaun Watson threw for 186 yards rushing for a decisive touchdown. Third-year running back Jerome Ford rushed seven times for 64 yards, averaging 9.1 yards per carry.
New York is in the second leg of back-to-back road games after a 21-18 setback at Washington last week. The Giants were blown out by Minnesota in their season opener and are just 1-8 in their last nine road games. The home-road splits are very important in this matchup, as the Browns have covered the spread in six of their last seven home games, which is one reason why the model has Cleveland covering nearly 60% of simulations. See which other teams to pick here.
Another of its Week 3 NFL betting predictions: the Bengals (-7.5, 47) cover against the Commanders. Washington is coming off a 21-18 win over the Giants where it became the first team in NFL history to win in regulation despite giving up three touchdowns and failing to score one of its own. However, the Commanders are still just 2-7 against the spread over their last nine games and they are 5-15 straight up in their last 20 appearances on Monday Night Football.
Meanwhile, the Bengals are 0-2 on the season but covered the spread as 6.5-point underdogs in Kansas City last week, losing on a last-second field goal by Harrison Butker. They are 4-1-1 against the number in their last six Monday night home games. Joe Burrow outplayed Patrick Mahomes last week and he should give Cincinnati a clear quarterback opposite fellow LSU Heisman Trophy winner Jayden Daniels. That is a big reason why the model says that Bengal covers more than 50% of simulations. See which other teams to pick here.
How to make Week 3 NFL picks
The model also made the call on who wins and covers in every other game on the Week 3 NFL schedule and just revealed three must-see underdogs who win outright, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence, and which three must-see underdogs should you lock up right now? Check out the latest NFL odds below then visit SportsLine to see which teams win and cover the spread, all from a tested computer model that returned well over $7,000.and find out.
Week 3 NFL betting odds, lines, spreads
Get Week 3 NFL picks at SportsLine
Sunday, September 22
Giants at Browns (-6.5, 38.5)
Bears at Colts (-1, 44)
Texans at Vikings (+1.5, 46.5)
Eagles at Saints (-2.5, 49.5)
Chargers at Steelers (-2.5, 35)
Broncos at Buccaneers (-6, 41)
Packers at Titans (-3, 37.5)
Panthers at Raiders (-6, 40)
Dolphins at Seahawks (-4.5, 41.5)
Lions at Cardinals (+3, 51.5)
Crows at Cowboys (+1, 47.5)
49ers at Rams (+6.5, 44)
Chiefs at Falcons (+3, 46.5)
Monday, September 23rd
Jaguars at Bills (-5, 45.5)
Commanders at Bengal (-7.5, 47)
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