The biggest favorite on the NFL schedule has lost the first three weeks of the season, which does not bode well for the San Francisco 49ers in Week 4. The 49ers are 10.5-point favorites over the Patriots according to the latest Week 4 NFL probability despite losing as six-point favorites to the Rams a week ago. San Francisco is without running back Christian McCaffrey, while receiver Deebo Samuel is nursing a calf injury and tight end George Kittle was a limited participant in practice this week. Should you follow the NFL trends and drop the Rams in your best Week 4 NFL bets or is this the week that a heavy favorite finally defies the NFL spreads? All Week 4 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and NFL predictions you need to make the best Week 4 NFL picks right now..
The model, which simulates each NFL game 10,000 times, raises well over $7,000 for $100 players on an A rating. NFL picks since its inception. The model enters Week 4 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks dating back to the 2017 season. It is also on a 41-22 list on A-rated NFL picks as of Week 7 of the 2022 NFL season.
The model has also ranked in the top 10 on NFLPickWatch four of the past six years on straight NFL picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who followed it is way up.
Now, it has turned its attention to the latest Week 4 NFL odds and NFL betting lines on the spread, moneyline, and over-under, and locked in picks for every NFL game. Go here to see each selection.
Top Week 4 NFL predictions
We can tell you that one of the model’s strongest Week 4 NFL picks is the Saints (+2.5, 42.5) covering the spread against the Falcons. These teams are only separated by a game in the NFC South standings but the Saints have certainly looked more compelling as NFC contenders over the first three weeks. Their offense erupted in wins over the Panthers and Cowboys, and then it took a late comeback by the Eagles to knock them off in a tough battle in Week 3.
Meanwhile, the Falcons couldn’t get things going offensively and they could have easily been 0-3 if not for some luck against the Eagles in Week 2 despite playing competitively in all three of their matchups. The Saints are 4-1 against the spread over their last five games dating back to last season while Atlanta is 1-4. That’s a big reason why the model has New Orleans covered in well over 60% of simulations. See which other teams to pick here.
Another of its Week 4 NFL betting predictions: the Steelers (-1.5, 40) cover on the road against the Colts. Pittsburgh has been one of the NFL’s most unlikely successes early in the season. The Steelers revamped their quarterback room by signing Russell Wilson in free agency and trading for Justin Fields, then naming Wilson the starter after a prolonged battle during the preseason.
However, Wilson was nursing a calf injury early in the season and Fields made the most of his opportunity, leading the Steelers to a 3-0 record while completing 73.3% of his passes, using his legs to extend plays and generally avoiding disaster. mistakes Meanwhile, the Indianapolis defense ranks second-to-last in the NFL in yards allowed and Anthony Richardson leads the NFL with six interceptions. That is a big reason why the model has the Steelers covering more than 50% of simulations. See which other teams to pick here.
How to make Week 4 NFL picks
The model also called who wins and covers in every other game on the Week 4 NFL schedule and just revealed three teams that win outright at least 70% of the time, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So, what NFL picks can you make with confidence, and which three must-see teams should you lock in right now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a tested computer model that returned well over $7,000.and find out.
Week 4 NFL betting odds, lines, spreads
Get Week 4 NFL picks at SportsLine
Thursday, September 26
Cowboys at Giants (+5.5, 45.5)
Sunday, September 29
Saints at Falcons (-2.5, 42.5)
Bengals at Panthers (+4, 47)
Rams at Bears (-3, 41)
Vikings at Packers (-2.5, 43.5)
Jaguars at Texans (-6.5, 45)
Steelers at Colts (+1.5, 40)
Broncos at Jets (-7.5, 39.5)
Eagles at Buccaneers (+2, 44)
Commanders at Cardinals (-3.5, 50.5)
Patriots at 49ers (-10.5, 40.5)
Browns at Raiders (-2, 37)
Chiefs at Chargers (+7.5, 40)
Bills at Ravens (-2.5, 46.5)
Monday, September 30th
Titans at Dolphins (-1, 36.5)
Seahawks at Lions (-3.5, 46.5)
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